解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The requirement of large amounts of the recombinant human bone morphogenetic protein-2 (BMP-2) produces a huge translational barrier for its routine clinical use due to high cost. This leads to an urgent need to develop alternative methods to lower costs and/or increase efficacies for using BMP-2. In this study, we de...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1615
更新日期:2009-12-01 00:00:00
abstract::The consumption of protein supplements containing amino acids is increasing around the world. Aspartate (Asp) and asparagine (Asn) are amino acids metabolized by skeletal muscle. This metabolism involves biochemical pathways that are involved in increasing Krebs cycle activity via anaplerotic reactions, resulting in h...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1606
更新日期:2009-12-01 00:00:00
abstract::Although techniques for purifying epidermal stem cells (ESCs) have been established, enriching a pure population of viable ESCs is still a challenging task. One approach toward enhancing the purity and viability of ESCs involves cell markers. While evidence suggests that p63 plays a role in maintaining the population ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1612
更新日期:2009-12-01 00:00:00
abstract::This study evaluated the effect of possible synergic interaction between high fat diet (HF) and hydrochlorothiazide (HCTZ) on biochemical parameters of oxidative stress in brain. Rats were fed for 16 weeks with a control diet or with an HF, both supplemented with different doses of HCTZ (0.4, 1.0, and 4.0 g kg(-1) of ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1599
更新日期:2009-10-01 00:00:00
abstract::Sperm associated antigen 8 (SPAG8), a testis-specific protein produced during male germ cell differentiation, was isolated from a human testis expression library using antibodies found in the serum obtained from an infertile woman. It was found to have a close functional relationship with microtubules. In this study, ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1574
更新日期:2009-07-01 00:00:00
abstract::Differences in metabolism of drugs can lead to severe toxicity or therapeutic failure. In addition to cytochrome P450 2D6, which plays a critical role in drug metabolism, ABCB1 encoded P-glycoprotein (PGP) is also an important determinant in drug bioavailability. The genes encoding these molecules are highly variable ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1561
更新日期:2009-06-01 00:00:00
abstract::The aim of the present study is to evaluate the proliferation- and migration-enhancing effects of ginseng and its component, ginsenoside (Rg1) on RSC96 Schwann cells. We investigated the molecular signaling pathways, which include: (1) survival signaling, IGFs-IGFIR-Akt-Bcl2 and proliferative signaling, cell cycle fac...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1554
更新日期:2009-06-01 00:00:00
abstract::Psoriasis is a common chronic and recurrent inflammatory skin disease with unknown etiology that has been associated with abnormal plasma lipid metabolism and oxidative stress. There are controversial results in the previous studies investigating oxidant/antioxidant systems in psoriasis.The aim of this work was to eva...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1553
更新日期:2009-04-01 00:00:00
abstract::Dietary soy lecithin supplementation decreases hyperlipidemia and influences lipid metabolism. Although this product is used by diabetic patients, there are no data about the effect of soy lecithin supplementation on the immune system. The addition of phosphatidylcholine, the main component of lecithin, to a culture o...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1517
更新日期:2008-12-01 00:00:00
abstract::The aim of this brief communication was to determine the correlation between pre-eclampsia (PE), Helicobacter pylori pathogenic strains seropositivity, and interleukin-18 (IL-18) levels. To this purpose 25 pre-eclamptic women and 25 healthy parturient women of similar age were evaluated for: IL-18 levels, by ELISAH. p...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1503
更新日期:2008-10-01 00:00:00
abstract::Human cytochrome P450 2J2 (CYP2J2) is abundant in cardiovascular tissue and active in the metabolism of arachidonic acid to eicosanoids that have potent vasodilatory properties. Variability of the CYP2J2 gene is highly constrained except for its proximal promoter: there is a relatively common and functionally relevant...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1512
更新日期:2008-10-01 00:00:00
abstract::We have shown previously the intercalation geometry of a series of acenaphtho [1,2-b] pyrrole derivatives with DNA double helix in vitro. In this report we chose a couple of intercalating analogues and a Chinese traditional medicine Tanshinone IIA as probes to investigate the response of DNA damage sensor ataxia-telan...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1510
更新日期:2008-10-01 00:00:00
abstract::Previously mildronate, an aza-butyrobetaine derivative, was shown to be a cytoprotective drug, through its mechanism of action of inhibition of carnitine palmitoyltransferase-1, thus protecting mitochondria from long-chain fatty acid accumulation and subsequent damage. Recently in an azidothymidine (AZT)-induced cardi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1486
更新日期:2008-09-01 00:00:00
abstract::We investigated the effect of rosiglitazone (RSG), a high-affinity ligand for the peroxisome proliferator-activated receptor gamma which mediates insulin-sensitizing actions, on the lipid profile and oxidative status in streptozotocin (STZ)-induced Type 2 diabetes mellitus (DM) rats. Wistar albino male rats were rando...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1469
更新日期:2008-06-01 00:00:00
abstract::Thyroid cells fall into the type of cells functioning during continuous production of high H(2)O(2) concentrations. We studied the effect of H(2)O(2)-induced oxidative stress (0.1, 1.0 and 10.0 mM) on the activities of the key steps of iodide metabolism (uptake, oxidation and organification) in thyrocytes cultivated i...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1452
更新日期:2008-04-01 00:00:00
abstract::The heart responds to an increased demand arising due to physiological stimuli or pathological insults by hypertrophy of myocytes. Reactive oxygen species (ROS) have recently been identified as the molecular intermediates in the translation of mechanical stimuli to cellular response. Different signal transduction path...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1449
更新日期:2008-04-01 00:00:00
abstract::We report a functional characterisation of the novel protein MGC13096. MGC13096 over-expression restrained proliferation of HEK293T cells. DNA/flow cytometry analysis showed that the over-expression of MGC13096 severely delays cell cycle progression at S phase. Transcription factors such as activator protein-1 (AP-1),...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1410
更新日期:2008-03-01 00:00:00
abstract::We examined the influence of chronic treatment with KN-93 (an inhibitor of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), 5 mg/kg given every other day for 4 weeks) on mean arterial pressure (MAP), urine protein and vascular reactivity in streptozotocin (STZ)-induced diabetes in Wistar Kyoto (WKY) and spontan...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1446
更新日期:2008-03-01 00:00:00
abstract::The molecular mechanisms involved in GPCR-initiated signaling cascades where the two receptors share the same signaling cascade, such as thyrotropin-releasing hormone (TRH) and angiotensin II (ANG II), are still far from being understood. Here, we analyzed hormone-induced Ca(2+) responses and the process of desensitiz...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1453
更新日期:2008-03-01 00:00:00
abstract::Bone tumor incidence in women peaks at age 50-60, coinciding with the menopause. That estrogen (E2) and triiodothyronine (T3) interact in bone metabolism has been well established. However, few data on the action of these hormones are available. Our purpose was to determine the role of E2 and T3 in the expression of b...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1408
更新日期:2008-01-01 00:00:00
abstract::The effects of 1,25-dihydroxyvitamin D3 are mediated by binding to a specific intracellular vitamin D receptor (VDR), which has been identified in a variety of tissues. Certain polymorphisms in the VDR gene have been associated with various neoplasms. For this purpose, we studied whether VDR TaqI or FokI genotype are ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1386
更新日期:2007-11-01 00:00:00
abstract::Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease that is characterized by selective destruction of insulin secreting pancreatic islets beta-cells. The formation of cytokines (IL-1beta, IL-6, TNF-alpha, etc.) leads to extensive morphological damage of beta-cells, DNA fragmentation, decrease of glucos...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1372
更新日期:2007-11-01 00:00:00
abstract::Betulin is a principal component of birch bark and is known to possess a broad range of biological activities, including antiinflammatory, antiviral and anticancer actions. The present study was carried out in vitro to clarify the influence of betulin on melanocortin (MC) receptor-ergic signalling by using COS-7 cells...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1427
更新日期:2007-09-01 00:00:00
abstract::Cyclophosphamide (CP) has potential urotoxicity such as hemorrhagic cystitis (HC). 2-Mercaptoethane sulfonate (mesna) has been widely used as an effective agent against CP-induced cystitis, but significant HC has still been encountered clinically. In recent studies, mesna was shown to be more effective if combined wit...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1347
更新日期:2007-09-01 00:00:00
abstract::The phospholipid profiles of the myocardium (from 10- and 18-day old chick embryos and 13-day old chick) and their in vitro response to the endogenous lipolytic enzymes (mainly of the phospholipase group) at pH 7.4 and 38 degrees C for 60 min were analyzed by TLC technology and densitometry. Cardiolipin (CL) was shown...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1422
更新日期:2007-09-01 00:00:00
abstract::The effect of the tryptophan hydroxylase inhibitor, PCPA methylester, the serotonin reuptake inhibitor fluoxetine and MAO-A inhibitor clorgyline on the serotonin content of rat immune cells was studied, using labelled antibodies and flow cytometry. Each molecule significantly increased in males the serotonin concentra...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1329
更新日期:2007-09-01 00:00:00
abstract::Familial Mediterranean Fever (FMF) is an autosomal recessive hereditary disease leading mostly to renal failure and nephrotic syndrome. The ultrastructure of kidney has not been fully investigated in FMF associated renal disease. The aim of this study is to provide further evidence on the ultrastructure of kidney in p...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1286
更新日期:2007-07-01 00:00:00
abstract::The melastatin-related transient receptor potential channel TRPM2 is a plasma membrane Ca(2+)-permeable cation channel that is activated by hydrogen peroxide (H(2)O(2)) as a consequence of oxidative stress although the channel activation by H(2)O(2) appears to represent a cell-specific process in cells with endogenous...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1310
更新日期:2007-07-01 00:00:00
abstract::The acute effects of isolated and combined L-alanine (L-Ala) and L-glutamine (L-Gln) on liver gluconeogenesis, ureagenesis and glycaemic recovery during short-term insulin-induced hypoglycaemia (IIH) were investigated. For this purpose, 24-h fasted rats that received intraperitoneal injection of regular insulin (1.0 U...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1319
更新日期:2007-03-01 00:00:00
abstract::In moderate physical exercise, the transition from predominantly anaerobic towards predominantly aerobic metabolism is a key step to improve performance. Increase in the supply of oxygen and nutrients, such as free fatty acids (FFA) and glucose, which accompanies high blood flow, is required for this transition. The m...
journal_title:Cell biochemistry and function
pub_type: 杂志文章,评审
doi:10.1002/cbf.1327
更新日期:2006-11-01 00:00:00
abstract::The aim of this study was to evaluate the role of mitochondria in the recovery of cardiac energetics induced by ischaemic preconditioning at reperfusion. Isolated rat hearts were aerobically perfused (control), subjected to global ischaemia and reperfusion (reperfusion), or subjected to 3 brief cycles of ischaemia/rep...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1294
更新日期:2006-11-01 00:00:00
abstract::Reactive oxygen metabolites play an important role in ischemia-reperfusion related gastric injury. Primary sources of reactive oxygen metabolites seem to be the xanthine/xanthine oxidase system and neutrophils accumulating within the reperfused tissue. Tissue myeloperoxidase activity is an important index of neutrophi...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1251
更新日期:2006-09-01 00:00:00
abstract::Diabetes is associated with increased reactivity of the renal vascular bed to endothelin-1 (ET-1). It has been observed that diabetes is associated with over-expression of ET(A)- and ET(B)-receptors in the rat renal cortex. However it is not known if these receptors are over-expressed in the renal artery. The objectiv...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1253
更新日期:2006-09-01 00:00:00
abstract::Thyroid hormones regulate energy metabolism and act on mitochondria which are an important source of free radicals in the cell. The pineal gland activates antioxidant systems via melatonin secretion and thus has a protective function in body tissues. The present study was conducted to determine the oxidative damage ca...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1254
更新日期:2006-09-01 00:00:00
abstract::In this study, immunolocalization of tenascin (TN), type IV collagen and histopathological changes in the liver of fetuses of pregnant Wistar albino rats treated with two doses of alcohol (1 and 5 g kg(-1) day(-1)) were determined. The samples of liver obtained from fetuses of rats on day 21 of gestation were evaluate...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1215
更新日期:2006-05-01 00:00:00
abstract::The purpose of this study was to investigate the oxidative status in experimental hypothyroidism and the antioxidant effect of taurine supplementation. Forty male Sprague Dawley rats were randomly divided into four groups (group 1, control; group 2, control + taurine; group 3, propylthiouracil (PTU); group 4, PTU + ta...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1198
更新日期:2006-03-01 00:00:00
abstract::Several polymorphisms in the CYP1A1 locus have been identified and their genotypes appear to exhibit population frequencies that depend on ethnicity. We studied two CYP1A1 polymorphic sites (position 4889 and 6235) in a group of 212 unrelated healthy individuals belonging to three different Mexican populations (106 Me...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1174
更新日期:2005-05-01 00:00:00
abstract::This study was designed to investigate the effect of L-carnitine in ischaemia and reperfusion of the rat kidney. Rats were randomly allocated into three groups. Group I (control group; n = 6) received no treatment. Group II (isotonic saline group; n = 6), received 2 ml of isotonic saline 15 min before the renal ischae...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1159
更新日期:2005-05-01 00:00:00
abstract::One of the most damaging effects of reactive oxygen species (ROS) is lipid peroxidation, the end-product of which is malondialdehyde (MDA). This study was aimed to evaluate erythrocyte MDA levels during fracture healing in rats. Thirty male rats were used and the rats were divided into two groups to serve as controls ...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1199
更新日期:2005-03-01 00:00:00
abstract::Reduced and oxidized glutathione (GSH and GSSG), protein-bound glutathione, lipid peroxidation and antioxidant enzyme activities were determined in the erythrocyte lysates and membranes of type I and II alcoholics in order to clarify the effect of age-of-onset and the duration of the alcohol consumption on erythrocyte...
journal_title:Cell biochemistry and function
pub_type: 杂志文章
doi:10.1002/cbf.1125
更新日期:2005-01-01 00:00:00